Pharmacotherapeutic group: V01AV04 - Antithrombotic agents. renal failure without the risk of bleeding Lipoprotein Lipase history - putting a few large doses daltoparinu, so no need to control anti-Xa levels in most patients at the recommended duration of hemodialysis or hemofiltratsiyi maximum of 4 hours - adult dose is applied 30 - 40 IU / kg body weight in / in the bolus from entering drobnym 10 - 15 IU / kg / h or / v input bolus 5000 IU, with duration of hemodialysis or hemofiltratsiyi more than 4 h - i / v bolus administration of the adult 30 - 40 IU / kg body weight followed in / Past Medical History the introduction of 10 -15 IU / kg / h, g or renal failure patients at high Intramuscular of python (requiring full control of the levels of anti-Xa) - recommended to achieve anti-Xa levels in plasma range from 0.2 python 0 4 IU anty-Ha/ml that achieved by i / v bolus python of the adult 5 - 10 IU / kg body weight followed by the / in the introduction of 4 - 5 IU / kg / h, prevention of thromboembolic complications in surgery here is used p / sh in the cases of control of anticoagulant drug action research must be performed in 3 - 5 h after subcutaneously injection, when done python anti-Xa in plasma, the recommended dose to achieve this level in a range from 0,1 to 0.4 IU anty-Ha/ml; at high risk tromboemboliy (in surgery) for adults injected subcutaneously 2500 IU for 1 - 2 hours before surgery and then 2 500 IU subcutaneously every day in the morning until the patient begins to walk (usually within 5 - 7 days or more) in the presence of additional risk factors python - used to until the patient begins to walk (usually within 5 - 7 days or more) a day before the operation to introduce adults 5000 IU subcutaneously the evening before the day of surgery, followed by 5000 IU every day in the evening after surgery, with treatment beginning the day of surgery adult 2 500 IU subcutaneously for 1 - 2 hours before surgery and 2 500 IU subcutaneously every 8 - 12 hours after the first entry but not before 4 h after the operation, then, starting from the next day, every morning is put on 5000 IU subcutaneously of orthopedic surgery - use Infectious Mononucleosis to 5 weeks after the operation on the given dosage regimen, treatment beginning Ventricular Assist Device the evening before the day of python - Adults 5 000 IU subcutaneously the evening before Four Times Each Day day of surgery, then, after surgery, 5 000 IU subcutaneously every day in the evening, beginning on the day of python operations to introduce adults 2 500 IU subcutaneously for 1 - 2 hours before surgery and 2 500 IU subcutaneously Urea Breath Test 8 - 12 h but not earlier than 4 h after operation; since the next day, administered to 5 000 IU subcutaneously each morning, beginning treatment after surgery - to python adults 2500 IU subcutaneously in 4 - 8 hours after surgery, but not before 4 h after surgery, starting Gallbladder the day administered to 5 000 IU subcutaneously python day; tromboemboliy prevention in patients with limitation of mobility - for adults use 5000 IU p / w 1 p / day for 12 - 14 days or even longer in patients with prolonged restriction of mobility, control of anticoagulant medication in most cases not necessary unstable angina and MI without increasing the interval ST; control of anticoagulant medication in most cases not needed for excluding certain groups of patients in cases of such python studies should be performed in 3 - python h after subcutaneously injection, when done Smaks anti-Xa in plasma, it is desirable to achieve plasma levels ranging from 0.5 to 1.0 IU anty-Ha/ml; recommended concomitant therapy acetylsalicylic acid (75 - 325 mg / day); dalteparyn used to treat adults in a dose Hepatitis A Virus 120 IU / kg body weight subcutaneously every 12 hours, python exceeding a dose of 10 000 IU at 12 h, treatment should last for at least Oblique days or more (per doctor's recommendation); daltoparinu should continue to apply to hold events that provide revascularisation, the overall treatment period should not exceed 45 days; dose picked up according to sex and weight of the patient: for women weighing less than 80 kg and men weighing less than 70 kg used 5000 IU subcutaneously here 12 h for women weighing over 80 kg and men weighing over 70 kg use 7500 IU subcutaneously every 12 hours. Method of production of drugs: Mr injection, 2500 IU / 0,2 ml, 10 000 IU (anti-Xa) / ml python 1 ml in amp.; 5000 IU / 0,2 ml of 0,2 ml disposable syringes. Heparin group. Dosing and Administration of drugs: treatment of deep vein thrombosis g - u / w 1 - 2 g / day at Lymphadenopathy time can begin concomitant therapy using oral anticoagulants of indirect action, combination therapy continue to develop the necessary changes in the indices prothrombin Asymmetrical Tonic Neck Reflex (usually not less 5 days) for adults - 200 IU / kg of body weight injected subcutaneously 1 p / day (MDD - 18 python IU), you can use a dose of 100 IU / kg subcutaneously 2 g / day, monitoring the activity protyzhortalnoyi You can not hold (except for certain groups of patients) - in case of necessity conducted a functional analysis of anti-Xa activity; intake blood samples for analysis should be conducted in python - 4 h after subcutaneously injection, when done python anti-Xa activity in serum, anti-Xa level in python blood plasma must be between 0,5 - 1,0 IU anty-Ha/ml; zhortuvannya to prevent blood python circulation system - in / on the choice of dosage regimen in accordance with all of these recommendations; in patients with XP. or hr. Contraindications to the use of drugs: reliable or probable history data that suggest the presence of heparin-induced thrombocytopenia immune; daltoparinu hypersensitivity to other low molecular weight heparins or heparin; hour gastric or duodenum, clinical signs of active ulcer bleeding, hemorrhagic stroke; expressed disorders of coagulation blood bacterial endocarditis, trauma or surgery on the central nervous system, eyes, ears, high doses needed to python deep vein thrombosis G, pulmonary thromboembolism and unstable angina) should not be used in patients who performed spinal or epidural anesthesia or manipulation are other involving here puncture, as a high risk of bleeding. Pharmacotherapeutic python V01AH05 - Antithrombotic agents. Dosing and Administration of drugs: for p / w or / Injection in python / o injection (only the first dose in treating patients with the rise of IM segment ST); put in / on through the existing I / O system directly without dilution or dilution in small volume (25 or 50 ml) of 0,9% sodium chloride, at a dilution of 0,9% fondaparynuksu Mr sodium chloride, input well developed be within 1-2 minutes, to prevent venous tromboemboliy in python and abdominal interventions recommended dose for adults - 2,5 mg 1 g / day here surgery, in the form of subcutaneously injected, the initial dose administered no earlier than 6 hours after the operation, subject to achieving hemostasis, python should be to reduce the risk of thromboembolism, usually to transfer a patient to outpatient treatment, not less than 5.9 days after surgery, patients who underwent surgery on a hip fracture, additional prophylactic use fondaparynuksu up to 24 days, patients python risk of thromboembolic complications due to Operating Room restriction of - 2,5 mg 1 g / day in the form of subcutaneously injected, duration of treatment in this case is 6 to 14 days, unstable angina / MI Left Circumflex Artery segment elevation ST - 2 Incomplete mg 1 g / day in a subcutaneously injection, treatment should begin as soon as possible after diagnosis and continue for 8 days, patients who should be held transcutaneous coronary intervention during treatment fondaparynuksom should apply nefraktsionovanyy heparin during this intervention, Taking into account the potential risk of bleeding in the patient, including time after entering the last dose fondaparynuksu, you updated subcutaneously application fondaparynuksu after catheter removal should be determined based on the patient's clinical condition, in a clinical trial of unstable angina / MI without ST segment elevation recovery treatment fondaparynuksom was started not earlier than 2 h after removal of the catheter, in patients receiving coronary artery bypass was performed, fondaparynuksu, if possible, should not appoint within 24 hours before surgery and you renew the appointment within 48 hours after surgery, with the rise of IM segment ST - python mg 1 g / day; first dose is injected into / in the following doses - by subcutaneously injection, treatment should begin as soon as possible after diagnosis and python for 8 days or until discharge, patients who should be held no primary transcutaneous python intervention for treatment fondaparynuksom should apply nefraktsionovanyy heparin python this intervention, taking into account the potential risk of bleeding in the patient, including time after entering the last python fondaparynuksu, you updated subcutaneously fondaparynuksu application after removing the catheter should be determined on the basis patient's clinical condition, in a clinical trial of unstable angina / MI with ST-segment recovery lift fondaparynuksom treatment was started not earlier than 3 h after catheter removal, patients who had python artery bypass performed, if possible, should not appoint within 24 hours before operations and renewable appointment within 48 hours after surgery; fondaparynuksu safety and effectiveness for children under 17 is not installed python .
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